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EU GMP ANNEX1 (Workshop 3)

  • Crystal palace BTC 8 Ameriška ulica Ljubljana, Ljubljana, 1000 Slovenia (map)

Speakers:

Main discussion topics:


ASEPTIC PROCESSSING

  • Contamination control system (CCS)

  • Annex applicability for low bioburden manufacturing areas

  • Sterilization of indirect product contact surfaces (as e.g. stopper bowls)

  • CCIT implementation

  • Pyrogen

  • “Cleanup” time during monitoring

  • Reside of disinfectants and related validation requirements

  • Smoke studies

  • Nonviable particle monitoring to ISO 14644-2:2015


IMPACT ON FACILITIES UPGRADE

  • Approach to upgrade existing facilities.

  • PUPSIT

  • Upgrading the zoning concept from Zone D to Zone C for “open isolators”?

  • Challenges to upgrade Traditional Viable EM (LIMS and Automatic Plate Counters)

  • Annex 1 and RABS vs Isolators

  • Exchange and alignment on CAPEX requirements